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Recent Selected Publications
Lu Z, Kou W, Du B, Wu Y, Zhao S, Brusco OA, Morgan JM, Capuzzi DM; Chinese Coronary Secondary Prevention Study Group. Effect of xuezhikang, an extract from red yeast chinese rice, on coronary events in a chinese population with previous myocardial infarction.
Am J Cardiol. 2008 Jun 15;101(12):1689-93. Epub 2008 Apr 11.
Kumar S, Malachowski WP, DuHadaway JB, LaLonde JM, Carroll PJ, Jaller D, Metz R, Prendergast GC, Muller AJ. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
J Med Chem.
2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.
Ramalingam A, Duhadaway JB, Sutanto-Ward E, Wang Y, Dinchuk J, Huang M, Donover PS, Boulden J, McNally LM, Soler AP, Muller AJ, Duncan MK, Prendergast GC. Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging.
Cancer Res. 2008 Mar 15;68(6):1683-90.
Murray LJ, Tully O, Rudolph DS, Whitby M, Valenzano MC, Mercogliano G, Thornton JJ, Mullin JM. Absence of Na+/sugar cotransport activity in Barrett's metaplasia.
World J Gastroenterol, in press (2008).
Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. O
ncogene. 2008 May 1;27(20):2851-7. Epub 2007 Nov 19.
Cox RH, Fromme SJ, Folander KL, Swanson RJ.
Voltage gated K(+) channel expression in arteries of Wistar-Kyoto and spontaneously hypertensive rats.
Am J Hypertens 21: 213-218 (2008).
Schreiber AL, Fried GW, Formal CS, DeSouza BX.
Rehabilitation of neuromyelitis optica (Devic Syndrome): three case reports.
Am J Phys Med Rehabil 87: 144-148 (2008).
Ezekowitz MD, Reilly PA, Nehmiz G, Simmers TA, Nagarakanti R, Parcham-Azad K, Pedersen KE, Lionetti DA, Stangier J, Wallentin L.
Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study).
Am J Cardiol 100: 1419-26 (2007).
Huang M, Duhadaway JB, Prendergast GC, Laury-Kleintop LD.
RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol 27: 2597-2605 (2007).
Chang MY, Boulden J, Katz JB, Wang L, Meyer TJ, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer.
Cancer Res 67: 7605-7612 (2007).
Ramalingam A, Prendergast GC. Bin1 homolog Hob1 supports a Rad6-Set1 pathway of transcriptional repression in fission yeast.
Cell Cycle 6: 1655-1662 (2007)
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Zugates GT, Peng W, Zumbuehl A, Jhunjhunwala S, Huang YH, Langer R, Sawicki JA, Anderson DG. Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s.
Mol Ther 15: 1306-1312 (2007).
Wei G, Hobbs CA, DeFeo K, Hayes CS, Gilmour SK. Polyamine-mediated regulation of protein acetylation in murine skin and tumors.
Mol Carcinog 46: 611-617 (2007).
Ramalingam A, Farmer GE, Stamato TD, Prendergast, GC. Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
Cell Cycle 6: 1914-1918 (2007)
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Metz R, DuHadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. Novel tryptophan catabolic enzyme IDO2 Is the preferred biochemical target of the antitumor IDO Inhibitory Compound D-1-methyl-tryptophan.
Cancer Res 67: 7082-7087 (2007).
Peng W, Anderson DG, Bao Y, Padera RF Jr, Langer R, Sawicki JA. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors.
Prostate 67:855-862 (2007).
Prendergast GC and Jaffee EM. Cancer immunologists and cancer biologists: why we didn't talk then but need to now.
Cancer Res 67: 3500-3504 (2007).
Ayene IS, Koch CJ and Krisch RE. DNA strand breakage by bivalent metal ions and ionizing radiation.
Int J Rad Biol 83: 195-210 (2007).
Hou DY, Muller AJ, Sharma MD, DuHadaway J, Banerjee T, Johnson M, Mellor AL, Prendergast GC, Munn DH. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses.
Cancer Res 67: 792-801 (2007).
Benz R, Schmidt R, Kelly K, Wolfson M.
Epoetin alfa once every 2 weeks is effective for initiation of treatment of anemia of chronic kidney disease.
Clin J Am Soc Nephrol 2: 215-21 (2007).
Chang MY, Boulden J, Sutanto-Ward E, DuHadaway JB, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression.
Cancer Res 67: 100-107 (2007),
Barry EL, Baron JA, Bhat S, Grau MV, Burke CA, Sandler RS, Ahnen DJ, Haile RW, O'Brien TG. Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
J Natl Cancer Inst 98: 1494-1500 (2006)
Samuels LE, Holmes EC, Hagan K, Gopalan R, Droogan C and Ferdinand F. The Thoratec implantable ventricular assist device (IVAD): initial clinical experience.
Heart Surg Forum 9: E690-2 (2006).
Hobbs CA, Wei G, DeFeo K, Paul B, Hayes CS, Gilmour SK. Tip60 protein isoforms and altered function in in skin and tumors that overexpress ornithine decarboxylase.
Cancer Res 66: 8116-22 (2006)
Muller AJ and Scherle PA . Targeting the mechanisms of tumoral immune tolerance with small molecule inhibitors.
Nature Rev Cancer 6: 613-25 (2006)
Hayes CS, DeFeo K, Lan L, Paul B, Sell C, Gilmour SK. Elevated levels of ornithine decarboxylase cooperate with Raf/ERK activation to convert normal keratinocytes into invasive malignant cells.
Oncogene 25: 1543-53 (2006).
Pressman MH and Benz RL. Quantifying the role of factors that limit attainment of K/DOQI urea reduction ratio dialytic goal.
Clin Nephrol 66: 98-102 (2006)
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Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.
Int J Cancer 118: 2344-9 (2006).
Parekh A, Jaladi R, Sharma S, Van Decker WA and Ezekowitz MD. Images in cardiovascular medicine. Case of a disappearing left atrial appendage thrombus: direct visualization of left atrial thrombus migration, captured by echocardiography, in a patient with atrial fibrillation, resulting in a stroke.
Circulation 114: e513-4 (2006).
Huang, M., Kamasani, U., Prendergast, G.C. RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
Oncogene 25: 1281-9 (2006).
Singh BN, Singh SN, Reda DJ, Tang XC, Lopez B, Harris CL, Fletcher RD, Sharma SC, Atwood JE, Jacobson AK, Lewis HD Jr, Raisch DW, Ezekowitz MD and Sotalol Amiodarone Atrial Fibrillation Efficacy Trial (SAFE-T) Investigators. Amiodarone versus sotalol for atrial fibrillation.
N Engl J Med 352: 1861-72 (2005).
Muller, A.J., DuHadaway, J.B., Donover, P.S., Sutanto-Ward, E., and Prendergast, G.C. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
Nature Med
11: 312-9 (2005)
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Muller AJ, Prendergast GC. Marrying immunotherapy with chemotherapy:
Why say IDO?
Cancer Res 65: 8065-8 (2005).
Mullin, J.M., Leatherman, J.M., Valenzano, M.C., Rendon Huerta, E., Verrechio, J. Smith, D. Snetselaar, K., Francis, M.K., Liu, M. and Sell, C. Ras mutation impairs epithelial barrier function to nonelectrolytes while increasing transepithelial resistance.
Mol Biol Cell 16: 5538-50 (2005).
Guo, Y., Cleveland, J., and O'Brien, T.G. Haploinsufficiency for ODC modifies mouse skin tumor susceptibility.
Cancer Res
65:
1146-9 (2005)
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Bao Y, Peng W, Verbitsky A, Chen J, Wu L, Rauen KA, Sawicki JA. Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes.
Prostate 64: 401-7 (2005).
Kim YJ, Sauer C, Testa K, Wahl JK, Svoboda RA, Johnson KR, Wheelock MJ, Knudsen KA. (2005). Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex.
J Cell Sci 118: 3883-94 (2005).
Peng, W., Chen, J., Huang, Y., and Sawicki, J. Tightly-Regulated Suicide Gene Expression Kills PSA-expressing Prostate Tumor Cells.
Gene Ther 12: 1573-80 (2005).
Paul B, Hayes CS, Kim A, Athar M, Gilmour SK. Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (-)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic mice.
Carcinogenesis 26: 119-24 (2005).
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