Scientific Publications

The following publications represent some important research that has taken place in the laboratories of the Lankenau Institute over the past couple of years. To learn more about a specific paper, click on it below.

• Metz, R, J DuHadaway, S Rust, DH Munn, AJ Muller, M Mautino & GC Prendergast. Zinc protoporphyrin-IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase.
  Mol. Cancer Ther. 9(6):1864-71 (2010). 
• Muller AJ, DuHadaway JB, Jaller D, Curtis P, Metz R, Prendergast GC. Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.
  Cancer Res. 2010 Mar 1;70(5):1845-53. Epub 2010 Feb 16. 
• Burns MR, Graminski GF, Weeks RS, Chen Y, O'Brien TG. Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.
  J Med Chem. 2009 Apr 9;52(7):1983-93.
• Kowey PR, Dorian P, Mitchell LB, Pratt CM, Roy D, Schwartz PJ, Sadowski J, Sobczyk D, Bochenek A, Toft E; Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial.Atrial Arrhythmia Conversion Trial Investigators.
  Circ Arrhythm Electrophysiol. 2009 Dec;2(6):652-9. Epub . 
• Liss M, Sreedhar N, Keshgegian AA, Sauter G, Chernick MR, Prendergast GC, Wallon UM (2009). Tissue inhibitor of metalloproteinase-4 (TIMP-4) is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
  Amer J Pathol 175: 940-946.
• Gerhart J, Pfautz J, Neely C, Elder J, Duprey K, Menko AS, Knudsen K, George-Weinstein M (2009). Noggin producing MyoD+ cells are crucial for eye development.
  Dev Biol 336: 34-41.
• Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L (2009). Dabigatran versus Warfarin in Patients with Atrial Fibrillation.
  N Engl J Med 361: 1139.
• Huang YH, Zugates GT, Peng W, Holtz D, Dunton C, Green JJ, Hossain N, Chernick MR, Padera RF Jr, Langer R, Anderson DG, Sawicki JA (2009). Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.
  Cancer Res 69: 6184-91.
• Murray LJ, Gabello M, Rudolph DS, Farrell CP, Morgan M, Martin AP, Underwood JC, Valenzano MC, Mullin JM (2009). Transmucosal gastric leak induced by proton pump inhibitors.
  Dig Dis Sci 54: 1408-17. 
• Scott GN, DuHadaway J, Pigott E, Ridge N, Prendergast GC, Muller AJ, Mandik-Nayak L (2009). The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.
  J Immunol 182: 7509-17. 
• Gabello M, Valenzano MC, Barr M, Zurbach P, Mullin JM (2009). Omeprazole Induces Gastric Permeability to Digoxin.
  Dig Dis Sci, Epub online Jun 10.
• Mullin JM, Skrovanek SM, Valenzano MC (2009). Modification of tight junction structure and permeability by nutritional means.
  Ann N Y Acad Sci 1165: 99-112.
• Ezekowitz MD, Connolly S, Parekh A, Reilly PA, Varrone J, Wang S, Oldgren J, Themeles E, Wallentin L, Yusuf S (2009). Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran.
  Am Heart J 157: 805-10.
• Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA (2009). Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.
  Proc Natl Acad Sci USA 106: 3426-30. 
• Levatan CS, Upham LV, Deng S, Laury-Kleintop L, Kery V, Nolan R, Quinlan J, Torres C, El-Hajj RJ (2008). Discovery of a human peptide sequence signaling islet neogenesis. Endocr Pract 14: 1075-1083.
• Sawicki JA (2008). Fetal microchimerism and cancer.
  Cancer Res 68: 9567-9569. 
• Muller AJ, Sharma MD, Chandler PR, Duhadaway JB, Everhart ME, Johnson BA, Kahler DJ, Pihkala J, Soler AP, Munn DH, Prendergast GC, Mellor AL (2008). Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.
  Proc Natl Acad Sci USA 105: 17073-78.
• Sirover WD, Siddiqui AA, Benz RL (2008). Beneficial hematologic effects of daily oral ascorbic acid therapy in ESRD patients with anemia and abnormal iron homeostasis: a preliminary study.
  Ren Fail 30: 884-889.
• Adekar SP, Takahashi T, Jones RM, Al-Saleem FH, Ancharski DM, Root MJ, Kapadnis BP, Simpson LL, Dessain SK (2008). Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain.
  PLoS ONE 3: e3023.
• Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ (2008). Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
  J Med Chem 51: 4968-77.
• Lu Z, Kou W, Du B, Wu Y, Zhao S, Brusco OA, Morgan JM, Capuzzi DM (2008). Chinese Coronary Secondary Prevention Study Group. Effect of xuezhikang, an extract from red yeast chinese rice, on coronary events in a chinese population with previous myocardial infarction.
  Am J Cardiol 101: 1689-1693. 
• Cox RH, Fromme SJ, Folander KL, Swanson RJ (2008). Voltage gated K(+) channel expression in arteries of Wistar-Kyoto and spontaneously hypertensive rats.
  Am J Hypertens 21: 213-218.